Ever wonder why supplement studies can’t agree? Simple: many are set up to miss the mark. After thousands of hours reviewing the literature, we’ve found that results are largely determined by four levers—before the first pill is swallowed:

• Quality of ingredients
  
• Quantity (dose)
  
• Regularity (how often)
  
• Duration (how long)
  

We’re not dismissing good science—controls, placebos, proper analytics all matter. But if these four levers are off, the conclusion is baked in from the start.

A plain-English analogy: water and a bath

A researcher tests whether water cleans the body.

1. He hands people sewer sludge. Shocking result: “Water doesn’t clean.” Quality matters.
   
2. He uses pure water, but gives one drop per person. Again: “Water doesn’t clean.” Dose matters.
   
3. He offers a proper bath, but only three days this month. Result: “Water underwhelms.” Regularity matters.
   
4. He allows daily baths for three days, then measures cleanliness at day 30. Mixed results. Duration matters.
   

Now swap “water” for a nutrient. Same logic.

Where supplement research often goes sideways

1. Inferior sources and delivery. If a form isn’t well absorbed, don’t expect results.
   
2. Ignoring synergy. Nature rarely delivers nutrients solo. An orange isn’t just vitamin C—it comes with calcium, folate, B1, and more. The closer a formula mirrors what God designed, the more your body recognizes it as worth absorbing.
   
3. Under-dosing by design. Many studies hover near the RDA/DRI—numbers meant to avoid deficiency, not to drive improvement. Testing a quarter of a practical health-supporting dose and calling it “no effect” proves little.
   
4. Timing vs. half-life. If a nutrient’s effect tapers after ~4 hours, a once-daily dose won’t move the needle. Frequency matters.
   
5. Too little time on the clock. Real change isn’t instant. For example, meaningful effects from vitamin C often don’t show up before about a month of consistent intake (and more time is needed for bigger health hurdles).
   

Bottom line

When studies use high-quality ingredients and delivery systems, at effective doses, taken regularly, for long enough, results tend to be meaningful. Don’t be dazzled by the alphabet soup after a name. Be impressed by the method: quality, quantity, regularity, and duration. That’s how you separate solid science from pre-baked outcomes.

General Works on Vitamin C

The following are some books on Vitamin C that are not only easy to read for the lay person, but they offer valuable perspectives on the significance of Vitamin C to your everyday health. Admittedly, much of the research cited contains the flaws mentioned in "A Note About Vitamin C Research," but they are good general guides to immerse yourself in when beginning your voyage to optimal health.

1. Curing the Incurable: Vitamin C, Infectious Diseases, and Toxins, 3rd Edition Paperback – August 1, 2011 by J. D. Levy.
2. Vitamin C: The Real Story, Paperback- 2008 by Steve Hickey and Andrew W. Saul.
3. Cancer and Vitamin C: 21st Century Edition, November 2017 by Ewan Cameron, Linus Pauling, Ewan M. Cameron.

What Makes PureWay-C Different?

Vitamin C-lipid metabolites: uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers by Dario Pancorbo, Carlos Vazquez, and Mary Ann Fletcher, 2008

Absorption rates and free radical scavenging values of vitamin C-lipid metabolites in human lymphoblastic cells by Benjamin S Weeks and Pedro P Perez, 2007

Vitamin C and Infection

1. Vitamin C and Infections,by Harri Hemilia, 2017.
2. Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection by Ba X. Hoang, Graeme Shaw, Willian Fang and Bo Han, 2020.
3. Role of vitamin C in preventing of COVID-19 infection, progression and severity, by Umar Shahbaz, Nazira Fatima, Samra Basharat, Asma Bibi, Xiaobin Yu, Muhammad Hussain and Maryam Nasrullah.
4. Discovery shows new Vitamin C Health Benefits, by David Stauth, 2004
5. Unwinding the potentials of Vitamin C in Covid-19 and other diseases: An updated review, by Nikhil Mehta,Purvi Pokharna, andSaritha R Shetty, 2022
6. Vitamin C in Human Health and Disease Effects, Mechanisms of Action, and New Guidance on Intake: by Wang Jay Lee.

Vitamin C and Wound Healing

Vitamin C Promotes Wound Healing: The Use of in Vitro Scratch Assays to Assess Re-Epithelialization by Benjamin S. Weeks, Ruiqin Fu and Mohammad Zaidi

Vitamin C and Heart Disease

1. Cardiovascular health through Vitamin C Intake, by Elizabeth Moxley, 2023
2. Therapeutic potential role of vitamin C in prevention and control of heart transplant rejection and cardiac allograft vasculopathy. A need for consideration by Idd J Kenedy, Jaynes F. Kabuhaya and Harold Mashauri, 2023
3. Effect of vitamin C on endothelial function in health and disease: A systematic review and meta-analysis of randomised controlled trials, by Ashor A.W., Lara J., Mathers J.C., Siervo M., 2014

Vitamin C, Cancer and Inflammation

1. Cytotoxicity of ascorbatelipoic acid, and other antioxidants in hollow fibre in vitro tumors by Casciari, J., Riordan, N. S. T. M. X., Jackson, J. & Riordan, H., 2001
2. Effects of high dose intravenous ascorbic acid on the level of inflammation in patients with rheumatoid arthritis by Mikirova, N., Rogers, A., Casciari, J. & Taylor, P., 2012.
3. High-Dose Vitamin C in Advanced-Stage Cancer Patients by Anna Zasowska-Nowak, Piotr Jan Nowak and Aleksandra Cialkowska-Rysz, 2021.
4. Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany, by Vollbracht, C. et al., 2011.
5. Pharmacological ascorbic acid supresses syngenic tumor growth and metastases in hormone-refractory prostate cancer by Pollard, H., Levine, M., Eidelman, O. & Pollard, M., 2012.
6. Pharmacologic ascorbic acid concentrations selectively kill cancer cells action as a pro-drug to deliver hydrogen peroxide to tissues: by Chen, Q et. al., 2005.
7. Stromal cell oxidation: a mechanism by which tumors obtain vitamin C. by Agus, D., Vera, J. & Golde, D., 1999.
8. Supplemental ascorbate in the supportive treatment of cancer Prolongation of survival times in terminal human cancer by Cameron, E., Pauling, L. & Leibovitz, B., 1979.
9. Targeting cancer vulnerabilities with high-dose vitamin C by Bryan Ngo, Justin M. Van Riper, Lewis C. Cantley and Jihye Yun, 2020.
10. Vitamin C deficiency in cancer patients by Mayland, C., Bennett, M. & Allan, K.,Palliat, 2005.

Vitamin D and Inflammation

*Role of vitamins D, E and C in immunity and inflammation, by Y B Shaik-Dasthagirisaheb, G Varvara, G Murmura, A Saggini, A Caraffa, P Antinolfi, S Tete', D Tripodi, F Conti, E Cianchetti, E Toniato, M Rosati, L Speranza, A Pantalone, R Saggini, M Tei, A Speziali, P Conti, T C Theoharides, F Pandolfi, National Library of Medicine, PMID: 23830380

The beneficial role of vitamin D in Alzheimer's disease, by Khanh Vinh Quôc Lu'o'ng 1, Lan Thi Hoàng Nguyên, National Center for Biotechnical Information, PMID: 22202127

Vitamin D and Autoimmune Diseases

Vitamin D and Autoimmune Rheumatic Diseases, by Lambros Athanassiou12, Ifigenia Kostoglou-Athanassiou3, Michael Koutsilieris2, Yehuda Shoenfeld, National Center for Biotechnology Information, April 21, 2023, PMID: 37189455

Vitamin K for Bone and Cardiovascular Health

*Growing Evidence of a Proven Mechanism Shows Vitamin K2 Can Impact Health Conditions Beyond Bone and Cardiovascular, by Katarzyna Maresz, National Center for Biotechnical Information, PMCID: PMC8483258

Studies on the Synergistic Interplay of Vitamin D and K for Improving Bone and Cardiovascular Health, by Vinita Singh, Shravali Jain, Satya Prakash and Monika Thakur, Online ISSN: 2322–0007

Vitamin D + K Better Together

Studies on the Synergistic Interplay of Vitamin D and K for Improving Bone and Cardiovascular Health, by Vinita Singh, Shravali Jain, Satya Prakash and Monika Thakur, 11/6/2022, Online ISSN: 2322–0007.

D-Mannose and UTI

Porru D, Parmigiani A, Tinelli C, Barletta D, Choussos D, Di Franco C, et al. Oral D-mannose in recurrent urinary tract infections in women: a pilot study. Journal of Clinical Urology 2014;7(3):208–213

National Library of Medicine, “Why D-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections . . .”, February 24, 2022

National Library of Medicine, “Consumption of cranberry as adjuvant therapy for urinary tract infections . . .”, September 2, 2021

National Library of Medicine, “Exploring the effect and mechanism of Hibiscus sabdariffa on urinary tract infection and experimental renal inflammation”, December 4, 2016

National Library of Medicine, “The Diuretic Effect in Human Subjects of an Extract of Taraxacum officinale Folium over a Single Day”, August 15, 2008.

Breast Cancer

Dietary bioactive diindolylmethane enhances the therapeutic efficacy of centchroman in breast cancer cells by regulating ABCB1/P-gp efflux transporter by Dhanamjai Penta, Priya Mondal, Jagadish Natesh, Syed Musthapa Meeran , The Journal of Nutritional Biochemistry, August 2021.

Prostate Cancer

Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells by Hien T. Le, Charlene M. Schaldach, Gary L. Firestone, Leonard F. Bjeldanes, Journal of Biological Chemistry, June 2003.

Muscle Recovery and Growth

Effects of Magnesium Supplementation on Muscle Soreness and Performance, Alyssum M Reno, Matt Green, Lauren G Killen, Eric K O'Neal, Kelly Pritchett, Zella Hanson, Journal of Strength and Conditioning Research, August 1, 2022 (PMID: 33009349)

Cardiovascular Health

The Importance of Magnesium in Clinical Healthcare by Gerry K. Schwalfenberg andStephen J. Genuis, Scientifica, September 28, 2017 (PMID: 29093983)

Glucosamine

Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? by Yves Henrotin, Ali Mobasheri, and Marc Marty, Arthritis Research & Therapy, January 30, 2012 PMID: 22293240

Indian Frankincense (Boswellia Serrata

Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis by Ganpeng Yu,1Wang Xiang, Tianqing Zhang, Liuting Zeng, Kailin Yang,7andJun Li, BMC Complementary Medicine and Therapies, July 17, 2020 (PMID: 32680575)

Chondroitin Sulfate

Chondroitin Sulfate Supplements for Osteoarthritis: A Critical Review, by Rui Brito, Diogo Costa, Carina Dias, Patrícia Cruz, andPaula Barros