Real Research

Have you ever wondered why research on nutritional supplements has resulted in conflicting findings? From our thousands of hours of analysis we have concluded that nutritional supplement research results are often pre-determined by the following factors:

  1. Quality of Ingredients
  2. Quantity administered
  3. Regularity of dosage
  4. Duration of consumption

We are not overlooking the basic methodological considerations like proper controls, placebo groups, and the appropriate analytical techniques, but the four factors above tend to influence in a major way the findings of the researchers.

Let us give you a simple analogy to make our point. Pretend that a researcher hypothesizes that water can be used to clean your body.

In order to test his hypothesis he selects a thousand people and gives them muddy sludge water out of a sewer. No matter how many subjects, how long the test or how much of this filthy water is given, the scientist is not going to conclude that water is appropriate for cleaning your body. Hence, the quality of the ingredients is important.

Now, let's give the subjects only pure and clean water to bath in, but they are given only one drop each. Again, the scientist is not going to find that water is appropriate for cleaning your body. Hence, the quantity of dosage is important.

Perhaps, the scientist provides pure water in a quantity appropriate for a bath, but he only allows the subjects to take a bath for three days throughout the month. Again, the scientist is not going to find that water is appropriate for cleaning your body. Hence, regularity of intake is important.

Finally, the subjects are given pure water in an amount that is appropriate for a bath and they are allowed to take the bath at least once a day. But, they can only bath for the first three days and the test for cleanliness will be done at the end of the month. You guessed it, the results are going to be mixed at best. Hence, the duration of the administration is important.

Such has been the case with nutritional supplement research. Much of the research has measured the impact of inferior sources of the supplements. If the supplement is not absorbed, there is little likelihood that it will be effective.

Another problem is that few researchers consider the synergistic relationship between the supplement examined and other elements necessary for good absorption. For example, an orange contains not only Vitamin C, but traces of Calcium, Folate, B1, etc. The more closely your supplement replicates nature as God created it, the more your body will see it as a good thing to be absorbed.

Secondly, the quantities administered in most studies are far below those necessary for any viable results. The reason for this is that most researchers presume that the MDR established by the USDA is meaningful when in fact the MDR barely sustains health, much less overcomes disease. Many studies have focused on less than 1/4 of the dosage generally considered necessary for health maintenance and improvement.

Another factor often overlooked in the research is the half life of the supplement. If your supplement looses it's impact after 4 hours, there is small chance that any significant results will be discovered from once daily administration.

Finally, if the methodology of the research uses high quality ingredients, proper doses and is administered at the proper times, the length of time before results will be seen must be seriously evaluated. From our analysis of the research, it is clear that the impact of Vitamin C, for example, is not observable before at least a month of intake. Of course, the time period is dependent upon the significance of the health issue being addressed.

So, there you have it. All of the research on nutritional supplements that we have evaluated and that uses high quality ingredients and delivery systems, administered in the proper dosage and multiple times a day for extended periods, has without exception found that most nutritional supplements can have a significant impact on oxidization (disease) within human cells.

Don't be impressed by the Ph.D. or M.D. behind a researcher's name. Look instead at the quality of the methodology behind their research.

General Works on Vitamin C

The following are some books on Vitamin C that are not only easy to read for the lay person, but they offer valuable perspectives on the significance of Vitamin C to your everyday health. Admittedly, much of the research cited contains the flaws mentioned in "A Note About Vitamin C Research," but they are good general guides to immerse yourself in when beginning your voyage to optimal health.

  1. Curing the Incurable: Vitamin C, Infectious Diseases, and Toxins, 3rd Edition Paperback – August 1, 2011 by J. D. Levy.
  2. Vitamin C: The Real Story, Paperback- 2008 by Steve Hickey and Andrew W. Saul.
  3. Cancer and Vitamin C: 21st Century Edition, November 2017 by Ewan Cameron, Linus Pauling, Ewan M. Cameron.
What Makes PureWay-C Different?

Vitamin C-lipid metabolites: uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers by Dario Pancorbo, Carlos Vazquez, and Mary Ann Fletcher, 2008

Absorption rates and free radical scavenging values of vitamin C-lipid metabolites in human lymphoblastic cells by Benjamin S Weeks and Pedro P Perez, 2007

Vitamin C and Infection
  1. Vitamin C and Infections,by Harri Hemilia, 2017.
  2. Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection by Ba X. Hoang, Graeme Shaw, Willian Fang and Bo Han, 2020.
  3. Role of vitamin C in preventing of COVID-19 infection, progression and severity, by Umar Shahbaz, Nazira Fatima, Samra Basharat, Asma Bibi, Xiaobin Yu, Muhammad Hussain and Maryam Nasrullah.
  4. Discovery shows new Vitamin C Health Benefits, by David Stauth, 2004
  5. Unwinding the potentials of Vitamin C in Covid-19 and other diseases: An updated review, by Nikhil Mehta,Purvi Pokharna, andSaritha R Shetty, 2022
  6. Vitamin C in Human Health and Disease Effects, Mechanisms of Action, and New Guidance on Intake: by Wang Jay Lee.
Vitamin C and Wound Healing

Vitamin C Promotes Wound Healing: The Use of in Vitro Scratch Assays to Assess Re-Epithelialization by Benjamin S. Weeks, Ruiqin Fu and Mohammad Zaidi

Vitamin C and Heart Disease
  1. Cardiovascular health through Vitamin C Intake, by Elizabeth Moxley, 2023
  2. Therapeutic potential role of vitamin C in prevention and control of heart transplant rejection and cardiac allograft vasculopathy. A need for consideration by Idd J Kenedy, Jaynes F. Kabuhaya and Harold Mashauri, 2023
  3. Effect of vitamin C on endothelial function in health and disease: A systematic review and meta-analysis of randomised controlled trials, by Ashor A.W., Lara J., Mathers J.C., Siervo M., 2014
Vitamin C, Cancer and Inflammation
  1. Cytotoxicity of ascorbatelipoic acid, and other antioxidants in hollow fibre in vitro tumors by Casciari, J., Riordan, N. S. T. M. X., Jackson, J. & Riordan, H., 2001
  2. Effects of high dose intravenous ascorbic acid on the level of inflammation in patients with rheumatoid arthritis by Mikirova, N., Rogers, A., Casciari, J. & Taylor, P., 2012.
  3. High-Dose Vitamin C in Advanced-Stage Cancer Patients by Anna Zasowska-Nowak, Piotr Jan Nowak and Aleksandra Cialkowska-Rysz, 2021.
  4. Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany, by Vollbracht, C. et al., 2011.
  5. Pharmacological ascorbic acid supresses syngenic tumor growth and metastases in hormone-refractory prostate cancer by Pollard, H., Levine, M., Eidelman, O. & Pollard, M., 2012.
  6. Pharmacologic ascorbic acid concentrations selectively kill cancer cells action as a pro-drug to deliver hydrogen peroxide to tissues: by Chen, Q et. al., 2005.
  7. Stromal cell oxidation: a mechanism by which tumors obtain vitamin C. by Agus, D., Vera, J. & Golde, D., 1999.
  8. Supplemental ascorbate in the supportive treatment of cancer Prolongation of survival times in terminal human cancer by Cameron, E., Pauling, L. & Leibovitz, B., 1979.
  9. Targeting cancer vulnerabilities with high-dose vitamin C by Bryan Ngo, Justin M. Van Riper, Lewis C. Cantley and Jihye Yun, 2020.
  10. Vitamin C deficiency in cancer patients by Mayland, C., Bennett, M. & Allan, K.,Palliat, 2005.
Vitamin D and Inflammation

*Role of vitamins D, E and C in immunity and inflammation, by Y B Shaik-Dasthagirisaheb, G Varvara, G Murmura, A Saggini, A Caraffa, P Antinolfi, S Tete', D Tripodi, F Conti, E Cianchetti, E Toniato, M Rosati, L Speranza, A Pantalone, R Saggini, M Tei, A Speziali, P Conti, T C Theoharides, F Pandolfi, National Library of Medicine, PMID: 23830380

The beneficial role of vitamin D in Alzheimer's disease, by Khanh Vinh Quôc Lu'o'ng 1, Lan Thi Hoàng Nguyên, National Center for Biotechnical Information, PMID: 22202127

Vitamin D and Autoimmune Diseases

Vitamin D and Autoimmune Rheumatic Diseases, by Lambros Athanassiou12, Ifigenia Kostoglou-Athanassiou3, Michael Koutsilieris2, Yehuda Shoenfeld, National Center for Biotechnology Information, April 21, 2023, PMID: 37189455

Vitamin K for Bone and Cardiovascular Health

*Growing Evidence of a Proven Mechanism Shows Vitamin K2 Can Impact Health Conditions Beyond Bone and Cardiovascular, by Katarzyna Maresz, National Center for Biotechnical Information, PMCID: PMC8483258

Studies on the Synergistic Interplay of Vitamin D and K for Improving Bone and Cardiovascular Health, by Vinita Singh, Shravali Jain, Satya Prakash and Monika Thakur, Online ISSN: 2322–0007

Vitamin D + K Better Together

Studies on the Synergistic Interplay of Vitamin D and K for Improving Bone and Cardiovascular Health, by Vinita Singh, Shravali Jain, Satya Prakash and Monika Thakur, 11/6/2022, Online ISSN: 2322–0007.

D-Mannose and UTI

Porru D, Parmigiani A, Tinelli C, Barletta D, Choussos D, Di Franco C, et al. Oral D-mannose in recurrent urinary tract infections in women: a pilot study. Journal of Clinical Urology 2014;7(3):208–213

National Library of Medicine, “Why D-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections . . .”, February 24, 2022

National Library of Medicine, “Consumption of cranberry as adjuvant therapy for urinary tract infections . . .”, September 2, 2021

National Library of Medicine, “Exploring the effect and mechanism of Hibiscus sabdariffa on urinary tract infection and experimental renal inflammation”, December 4, 2016

National Library of Medicine, “The Diuretic Effect in Human Subjects of an Extract of Taraxacum officinale Folium over a Single Day”, August 15, 2008.

Breast Cancer

Dietary bioactive diindolylmethane enhances the therapeutic efficacy of centchroman in breast cancer cells by regulating ABCB1/P-gp efflux transporter by Dhanamjai Penta, Priya Mondal, Jagadish Natesh, Syed Musthapa Meeran , The Journal of Nutritional Biochemistry, August 2021.

Prostate Cancer

Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells by Hien T. Le, Charlene M. Schaldach, Gary L. Firestone, Leonard F. Bjeldanes, Journal of Biological Chemistry, June 2003.

Muscle Recovery and Growth

Effects of Magnesium Supplementation on Muscle Soreness and Performance, Alyssum M Reno, Matt Green, Lauren G Killen, Eric K O'Neal, Kelly Pritchett, Zella Hanson, Journal of Strength and Conditioning Research, August 1, 2022 (PMID: 33009349)

Cardiovascular Health

The Importance of Magnesium in Clinical Healthcare by Gerry K. Schwalfenberg andStephen J. Genuis, Scientifica, September 28, 2017 (PMID: 29093983)

Glucosamine

Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? by Yves Henrotin, Ali Mobasheri, and Marc Marty, Arthritis Research & Therapy, January 30, 2012 PMID: 22293240

Indian Frankincense (Boswellia Serrata

Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis by Ganpeng Yu,1Wang Xiang, Tianqing Zhang, Liuting Zeng, Kailin Yang,7andJun Li, BMC Complementary Medicine and Therapies, July 17, 2020 (PMID: 32680575)

Chondroitin Sulfate

Chondroitin Sulfate Supplements for Osteoarthritis: A Critical Review, by Rui Brito, Diogo Costa, Carina Dias, Patrícia Cruz, andPaula Barros